Virus pathogen database and analysis resource vipr. The rubella virus is a member of the genus rubivirus in. Laboratory diagnosis is required in all cases, although epidemics occasionally provide enough clinical and epidemiologic clues for a presumptive etiologic diagnosis. Old world alphaviruses are best known for causing rheumatic disease in humans. Virions are 70 nm in diameter, enveloped, and ether sensitive. Horses also may be severely or fatally infected, by equine encephalitis. The outer membrane is a lipid bilayer containing specialized glycoproteins e1 and e2 believed to be responsible for attachment to host cells.
When rubella virus infects susceptible women early in pregnancy, it may be transmitted to the fetus and may cause birth defects. No file size restrictions, no ad watermarks just a free online tool for creating pdfs from your ppt slides. The central theme of baltimore system of virus classification is all viruses must synthesize positive strand mrnas from their genomes, in order to produce proteins and replicate themselves. Infections usually resolve once antiviral antibody is produced. The complete genetic information either dna or, in some viruses, rna of an organism, typically expressed in the number of basepairs virus classification is the process of naming viruses and placing them into a taxonomic system. We also acknowledge previous national science foundation support under grant numbers 1246120, 1525057. Papovaviruses are one of the four important dsdna viruses e. Rubella virus ru of man was one of the first nonarbo. The alphavirus virions are assembled into icosahedral particles of approximately 70 nm in diameter and the particle core 40 nm consists of 240 copies of the capsid protein c or cp arranged in a t4 symmetry surrounding the genomic rna.
New world viruses and old world viruses, to which chikv belongs. Rubivirus is immunologically distinct from the other togaviruses. Pdf converter is a online webbased document to pdf converter software. This chapter focuses on togaviridae family whose two member genera are alphavirus and rubivirus. In the powerpoint preferences dialog box, click general. Pdf medical microbiology 8th edition ebook free fbfa.
The baltimore virus classification biology libretexts. This book covers topics such as the biochemistry of rotaviruses and the biological and medical challenges they pose. Instantly convert text documents, presentations, spreadsheets and images to pdf format with this free online pdf converter. Rubella virus replication and links to teratogenicity.
Furtado flores3 1virginiamaryland regional college of veterinary medicine, virginia tech, blacksburg, virginia, usa. Lecture powerpoint to accompany foundations in microbiology. Some alphavirus species produce severe encephalitis in humans. The outer membrane is a lipid bilayer containing specialized glycoproteins e1 and. Viruses can be placed in one of the seven following groups. Biology, structure, replication deals with the biology, structure, and replication of rotaviruses. Poxvirus infections typically result in the formation of lesions, skin nodules, or disseminated rash. Ch 20 lecture presentation free download as powerpoint presentation. Togaviridae definition of togaviridae by medical dictionary. Members of the togaviridaeare responsible for two very different kinds of human disease. This eight edition textbook of medical microbiology is written for a thorough, clinically relevant understanding of microbes and their diseases. Save powerpoint presentations as pdf files office support. The togaviridae family is organized into two genera, alphavirus and rubivirus.
The changes caused by the specific virus can also be produced by noninfectious. The role of the cellmediated response is less well known but is probably important. Rubivirus rubella virus, the other togavirus genus, is discussed in. Brief overview of general features of togaviruses, bunyaviruses, reoviruses, arenaviruses and flaviviruses discussion of ecology, epidemiology and public health arbovirus encephalitis, febrile and hemorrhagic disease rodent borne hemorrhagic fever, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Chikungunya virus chikv is an arbovirus belonging to the genus alphavirus, family togaviridae. No known arterivirusescause disease in humans, so this genus is not discussed further. Nucleocapsids bind to the regions of the host cell membranes with these inserted proteins and bud into the extracellular space. Poxviruses exist throughout the world and cause disease in humans and many other types of animals. The togavirus genera are alphavirus, which is carried by mosquitoes, and rubivirus, which contains rubella, or german measles, virus. Alphavirus a sindbis b semliki forest c venezuelan equine encephalitis d eastern equine encephalitis e western equine encephalitis f chikungunya 2. Alphaviruses togaviridae and flaviviruses flaviviridae. Pages in category togaviruses the following 5 pages are in this category, out of 5 total. For most arthropodborne and rodentborne viruses, acutephase serum samples collected within 3 or 4 days of onset have yielded isolates. Arboviruses and other zoonotic viruses microbiology book.
The virus is enveloped and forms spherical particle of 6570 nm diameter. The picornaviridae family picornaviruses causes a wider range of illnesses than most other, if not all, virus families. Ch 20 lecture presentation meningitis central nervous. Classified originally on the basis of being small nonsegmented positive sense single strand rna viruses the classification was anything but precise. The general characteristics of togaviruses are summarized in table 1. Brain imaging abnormalities in cns virus infections unlike bacterial and fungal meningitis in which imaging abnormalities are not specific for a particular agent, many virus infections of the cns produce mri abnormalities not seen by any other infectious agent.
General characteristics, structure and taxonomy of viruses. Convert and create pdf from various types of files like word doc, excel xls, powerpoint ppt. Humans, mammals, birds, and mosquitoes serve as natural hosts. Decisions on new names, which encapsulate the recognition of natural groups of viruses, evolve slowly. The togaviruses are associated with mild systemic disease and encephalitis onset of symptoms includes nausea, vomiting, headache, fever, muscle ache, malaise, and leukopenia. Download as ppt, pdf, txt or read online from scribd. Viral proteins are inserted into the host cell membrane. Poxviruses are brick or ovalshaped viruses with large doublestranded dna genomes. Alphavirus, which includes eastern equine encephalitis, western equine encephalitis, and venezuelan equine encephalitis virus, and rubivirus, the rubella virus. Togaviruses, flaviviruses, some bunyaviruses and reoviruses most illnesses caused by these viruses are mild fevers. It affects children and adolescents worldwide and can also affect young adults.
Coronaviruses is the property of its rightful owner. Neuroimages brain imaging abnormalities in cns virus. Which of the following is an important factor for the classification of a virus within the 22 families of mammalian viruses. A description of clinical manifestations of togaviral infections. Therefore, accurate diagnosis is critical in pregnancy. Togaviruses attach to the surface of a cell using the glycoprotein spikes that cover the virion surface, and are absorbed into the cell. Baltimore system of classifications of viruses microbeonline. Rubella virus is the only member of togavirus family that causes significant disease in humangerman measles. Togaviruses induce interferon and are susceptible to its effects. Medical microbiology 8th edition ebook pdf free download edited by murray, rosenthal and pfaller published by elsevier. Follow these instructions to set the print quality of the pdf. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Alphaviruses togaviridae and flaviviruses flaviviridae medical. The sole member of the rubivirus genus is the rubella virus.
Infection with various picornaviruses may be asymptomatic or may cause clinical syndromes such as aseptic meningitis the most common acute viral disease of the cns, encephalitis, the common cold, febrile rash illnesses. This free online converter allows to convert various file formats doc, docx, xls, ppt, jpg, png. The togaviridae togaviruses can be classified into thefollowing major genera. Much like the classification systems used for cellular organisms, virus classification is the subject of ongoing debate and proposals. In volunteer studies, infection can be induced by aerosol presentation to the nasopharyngeal mucosa. Viruses introduction to viruses u virus originates from latin word poison. Consequently nonarthropodborne nonarboviruses of the togavirus family, too, had to be expected. Under print quality paper pdf, set the desired quality to an option of your choice. Diseases associated with alphaviruses include arthritis and encephalitis. Togaviruses are important veterinary pathogens, and are transmitted via mosquitoes.
Since its inception, the members of the virus family togaviridae have been anything but constant. Classifying viruses according to their genome means that those in a given category will all behave in a similar fashion, offering some indication of how to proceed with further research. As shown in tables 541 and 542, alphaviruses and flaviviruses can cause various syndromes, ranging from. Alphaviruses are mainly arthropod borne viruses and responsible for such diseases in humans as encephalitis, and arthritis. Hemagglutination inhibition test is widely used for the diagnosis of infection caused by orthomyxoviruses influenza, paramyxoviruses measles, mumps, mononucleosis, abrovirusestogaviruses including rubella, flaviviruses, and bunyaviruses. The precise mechanisms whereby this is achieved differ. Clinical features rubella and its complications the virus is transmitted from person to person via respiratory aerosols. Viruses 1 eukaryotic microorganisms and viruses ws 20102011 virus latin.
Some variability in presentation occurs as illustrated by the recent report from. Molecular characterization of the isolated viruses 151 metabolic and other cellular processes can be used for measuring the degree of relatedness between greatly divergent common ancestors, the information of which is used to generate a phylogenetic tree which graphically represents such relationships wagner et al. Prevention without knowledge of the agent, based on recognition that survivors of smallpox were subsequently protected against disease inoculation of healthy individuals with dry material from. Alphavirus is one of two genera in the family togaviridae. In this article we will discuss about the structure and replication of togaviruses. Togavirus definition of togavirus by medical dictionary. Togaviruses are important zoonoses with humans becoming infected as a. General characteristics, structure and taxonomy of viruses 6dec2004 g. Rubella german measles is a common mild disease characterized by a rash. Official approval for new names depends upon a series of sequential steps. All togaviruses contain a single strand of positive sense rna as their genetic. At least 27 alphaviruses and 68 flaviviruses have been recognized, approximately onethird of which are medically important human pathogens. This medical microbiology, 8th edition is edited by murray, rosenthal and pfaller.
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